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Major Mechanisms of Protection Against Autoimmunity

Our immune system has several mechanisms that protect us against autoimmunity. One of the most important mechanisms is oral tolerance, which allows us to ignore non-pathogenetic substances. This starts early in the womb and is maintained throughout life.

Functional Medicine plays a crucial role in safeguarding our immune system against the risks of autoimmunity. Among the various protective mechanisms, oral tolerance holds great significance. This mechanism enables us to disregard non-pathogenetic substances, thereby preserving our overall health and well-being. Interestingly, this innate defense mechanism begins its operation even before birth and continues to function throughout our lifetime.

The Role of Oral Mucosal in Immune System for AutoImmunity

The Barrier of Mucosal Lining

The oral mucosal lining is our initial defense against pathogens, allergens, and chemicals. It protects our body from external environmental exposures, toxins, and microbes.

Composed of stratified epithelial cells and cell to cell junctions. The oral cavity or human mouth consists of nearly 700 different forms of microorganisms .

The Microbiological Immunity Barrier

The microbiological immunity barrier controls and regulates the internal environment to maintain homeostasis.

It plays a major role in the gut and mucosal lining surrounding it. Keeping our internal bodies in homeostasis.

The Importance of Acidic Stomachs

Acidic stomachs are important for the destruction of harmful bacteria and other single-celled microbes before they reach the small and large intestines. This is crucial for our overall gut health and immune system function. Bile and exocrine pancreas secretion to the duodenum

The Role of IgA Antibodies and Lymphocytes in AutoImmunity


IgA Antibodies

IgA antibodies are found within the gut’s mucosal lining and are made up of the largest collection of lymphoid tissue and lymphocytes.


T Reg Cells

T Reg cells help keep the immune system in homeostasis and prevent the body from attacking itself, which can cause a drastic increase in inflammation. 


B Cells and T Cells

B Cells act as the second responder or the delayed response and are responsible for making antibodies to tag antigens so that the immune system builds a memory for them in times to come. T Cells and B Cells work together to maintain oral tolerance and prevent sensitivities, allergies, inflammation, and autoimmune disorders.

How Oral and Gastrointestinal Infections Affect the Immune System


Oral and gastrointestinal infections can sabotage homeostasis, leading to infection, medications, toxins, peptides, or dietary protein digestion.

Blood Sugar

Blood sugar imbalances can weaken the digestive system’s function, leading to a breakdown of the immune system.

The Gut-Immune Connection to AutoImmunity

How the Gut and Immune System are Connected

The gut and immune system are interconnected, and the gut is where the majority of the immune system resides. A healthy gut is essential to maintaining overall physical and mental health. Gut and brain are connected in numerous ways, including neurotransmitters. Which stem from the gut microbiome or mucosal layer to the blood brain barrier.

The Gut-Brain Connection

There are many neurons in the nervous system that connect gut to brain but, the largest being the vagus nerve. A reduce function of vagus nerve can lead to IBS and other gut issued associated. Gamma core can be used to stimulate the vagus nerve and help aid in digestion as well as passing nutrients through the blood brain barrier. This nerve stimulation can reduce headaches, anxiety, and fatigues.

The Role of Probiotics in the Connection

Probiotics can help improve gut health by supporting the microbiome and enhancing the microbiological immunity barrier. This can lead to better immune function and reduced inflammation. Signs of a healthy gut can range from increased energy levels, healthy reactions to foods and stressors, more mental clarity, and healthy and regular pain free bowel movement. Lactoferrin and Lactoperoxide are protective chemicals produced in the mucosal lining by the microbiome.

The Impact of Diet on the Immune System

The Standard American Diet (SAD)

The Standard American Diet (SAD) is high in processed foods refined sugars and inflammatory fats and this can lead to gut dysbiosis inflammation, and weakened immune system

The Role of Fiber for Gut Health

Fiber is essential for overall gut health and a strong immune system. It helps support the microbiome and be improved gut function. Aim for at least 25-30 grams of fiber per day

The Importance of Whole Foods

Eating a diet rich in whole foods like fruits, vegetables, nuts, seeds and lean proteins can provide the body with essential nutrients and antioxidants to support a healthier immune system.

Maintaining a Strong Immune System for AutoImmunity

Maintain a Healthy Gut

  • Eat whole, unprocessed foods
  • Incorporate fiber-rich foods
  • Take probiotics

Reduce Stress

  • Practice meditation or mindfulness
  • Incorporate movement like yoga or walking
  • Get enough sleep

Choose Immune- Boosting Foods

  • Eat antioxidant-rich foods like berries and leafy greens
  • Incorporate immune- boosting herbs and spices like turmeric and ginger, also help to reduce inflammation.
  • Choose lean proteins

AutoImmunity at Hope Brain and Body Recovery Center

Discover a better path with AutoImmunity. Schedule your appointment with Hope Brain and Body Recovery Center today and unlock the power of functional medicine. Take control of your health now!

We are located at 6 Dickinson Dr suite 310 Building 300, Chadds Ford, PA 19317, United States. You can also call us on (610) 544-9800 or contact us by completing the form. 


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